Inside the Ouroboros of Cleopatra the Alchemist

Inside the Ouroboros of Cleopatra the Alchemist - A single leaf in Venice preserves one of alchemy’s most famous emblems: an ouroboros encircling the words “hen to pan.” Meet the elusive Cleopatra the Alchemist and the late-antique toolkit she drew in the margins.

How a single page sketched a whole philosophy of turning things into gold

Push open a heavy reading-room door and imagine a single leaf under glass: a serpent biting its tail, half light and half dark, wrapped around three Greek words, hen to pan. Nearby are tiny moons, a ring of letters, and a few odd doodles that look like a still with two spouts. This is the Chrysopoeia of Cleopatra, a one-page wonder copied a thousand years ago that still hums with laboratory heat.

The page lives today in Venice, bound into a manuscript known as Marcianus gr. Z. 299. It’s a medieval copy of a late-antique scheme for chrysopoeia, gold-making, and one of the earliest alchemical images to marry symbol and benchwork. The ouroboros gives you the thesis; the tubing and vessels show you the practice.

Chrysopoea of Cleopatra — ouroboros encircling the motto “hen to pan”

You can read its motto in a breath. “The all is one.” Three words, a circle, and a promise that matter and meaning loop back on themselves. It’s the kind of phrase you might see on a café chalkboard, except here it’s inked beside labware.

The elusive Cleopatra

The author credited is Cleopatra the Alchemist, a name that floats through Greek and later Arabic alchemical writings. She is not Cleopatra VII of movie fame; this Cleopatra sits in Alexandria’s late Roman world, the bustling crossroads where glass-workers, dyers, and philosophers shared tricks of fire. Some historians treat “Cleopatra” as a single writer; others suspect a pseudonym that carried authority across centuries. Either way, she’s the rare woman remembered inside a largely anonymous craft.

What’s on the page

Look closer at the diagrams. One shows a dibikos, a two-armed alembic that splits condensed vapors into twin receivers. Another resembles a kerotakis, a device that bathed metals in sealed vapors. There are planetary marks for gold, silver, and mercury, a crescent and stars, and a circular text ring like a clock face. The whole sheet reads like a lab whiteboard annotated by a poet.

A tiny atlas of the Great Work

The ouroboros here is more than a mascot. Its split light-and-dark body hints at pairs alchemists loved to juggle: moist and dry, hot and cold, above and below. The ring of letters and nested crescents feel almost musical, a fugue of operations, calcine, dissolve, distill, recombine, repeating until base matter “ripens.”

Meanwhile, Cleopatra’s name surfaces beside titles like “On Weights and Measures” and a dialogue with philosophers, suggesting a mind as interested in measurement as in metaphor. Practical alchemy needed scales and clockwork patience; her page plants both feet on the ground.

Who believed what

Centuries later, the courtly alchemist Michael Maier would celebrate Cleopatra among the few women said to know the philosopher’s stone, a claim impossible to prove, delicious to imagine. The Venice leaf is safer ground. It shows us a working language of distillation and transformation, shared by glassmakers and pigment-mixers as much as by seekers of gold.

How to see it (and what to look for)

The Venice codex isn’t a casual drop-in, but reproductions travel widely. When you meet the image, trace these details:

  • The three-word motto inside the serpent.
  • The double-spouted still (dibikos) and the sealed vapor plate (kerotakis).
  • The crescent-and-star cluster, a wink toward lunar cycles and metal “temperaments.”
  • The serpent’s two tones, a visual shorthand for balancing opposites.

Spend a minute with the circle, and you may hear the quiet clink of glass, the whisper of steam, and a reminder that in old workshops, philosophy was something you could boil. This practical approach to alchemy, combining visual symbolism with laboratory technique, was shared by other Alexandrian alchemists like Zosimos of Panopolis, whose writings would become foundational texts in the alchemical tradition.


  • Biblioteca Nazionale Marciana (Venice), home of Marcianus gr. Z. 299, the alchemical codex that preserves the page.
  • Ouroboros, a world-straddling symbol that slithered from temples into laboratories.
  • Zosimos of Panopolis, Cleopatra’s near-contemporary whose writings fix much of early Greek alchemy on the map.

FAQ

Did Cleopatra the Alchemist really exist?
Probably, though “Cleopatra” may have functioned as an authorial mask in a tradition that loved anonymity. The name marks a voice within a known circle of Alexandrian experimenters.

Is the ouroboros here the first in alchemy?
It’s among the earliest alchemical ouroboroi tied to a concrete “how-to,” and certainly the most reproduced.

What does hen to pan actually imply for alchemists?
Unity: that matter changes form without losing an underlying oneness. In the lab, that meant recycling, recombining, and trusting cycles.

Did Cleopatra invent the alembic?
Attribution varies. Some traditions credit Mary the Jewess; others point to Cleopatra. What’s clear: Cleopatra’s diagram shows a sophisticated still already at work.

Can I visit the original page?
Scholarly access runs through the Marciana Library in Venice. For most of us, faithful images in catalogues and museum reproductions offer the closest view.

Why Venice, not Alexandria?
Manuscripts migrate. This one survived the long relay of copying and collecting and ended up in a Venetian codex that became a key witness to Greek alchemy.